פענוח בדיקת מח עצם

שלום, עזרתך בתרגום של תוצאות מח עצם לברר fuo. Two cores 1.3cm and 0.4 cm long each of normocellular for age bone marrow (60-70%).. There are numerous (at least 20) non-necrotizing granulomas consisting of epithelioid histiocytes, some of them with foamy cytoplasm and few giant cells. The residual hematopoietic tissue shows normal trilineage maturation with mild non specific megakaryocytic atypia, most probably reactive. There is diffuse increase of the reticulin fibers (1/3) mainly in the areas of the granulomas. Special stains for. microorganisms including GMS, Ziel-Neelsen and PAS are negative. Immunohistochemical stains show trilinear staining with MPO, Factor8 and Hemoglobin. The CD3 highlights scattered small T lymphocytes with formation of small interstitial aggregates. ISH EBV (EBER) and PARVO immunosttain are negative. Conclusion: Normocellular for age bone marrow showing granulomatous inflammation, with numerous non- necrotizing granulomas. No microrhganisms are identified by the above described histochemical stains. The rest of the. hematopoietic tissue shows reactive changes. e