אומגה 3 - טוב ללב, רע לפרוסטטה
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Omega-3 may up aggressive prostate cancer Published: April 27, 2011 at 7:22 AM SEATTLE, April 27 (UPI) -- High levels of omega-3 in the blood -- which is good for the heart -- may boost the risk of aggressive prostate cancer in men, U.S. researchers found. Theodore M. Brasky and colleagues at the Fred Hutchinson Cancer Research Center in Seattle analyzed data from a nationwide study involving more than 3,400 men. Half developed prostate cancer during the course of the study and half did not. The study, published in the American Journal of Epidemiology, found men with the highest blood percentages of docosahexaenoic acid, or DHA -- an inflammation-lowering omega-3 fatty acid commonly found in fatty fish such as salmon -- have two-and-a-half-times the risk of developing aggressive, high-grade prostate cancer compared to men with the lowest DHA levels. In addition, the study found men with the highest blood ratios of trans-fatty acids -- linked to inflammation and heart disease and abundant in processed foods that contain partially hydrogenated vegetable oil -- had a 50 percent reduction in the risk of high-grade prostate cancer. Neither fat was associated with the risk of low-grade prostate cancer risk. "We were stunned to see these results and we spent a lot of time making sure the analyses were correct," Brasky said in a statement. "Our findings turn what we know -- or rather what we think we know -- about diet, inflammation and the development of prostate cancer on its head." However, overall, the beneficial effects of eating fish to prevent heart disease outweigh any harm related to prostate cancer risk, Brasky adds.
אומגה 3 זה אחד החומרים החשובים לחולים עם סרטן הערמונית. להלן מאמר עם תוצאות הפוכות לחלוטין מאלה המובאות במחקר שהובא כאן ד"ר יוסף ברנר Display Settings:AbstractFormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListApply Send to:Choose DestinationFileClipboardCollectionsE-mailOrderMy Bibliography FormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File 1 selected item: 19318492FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailAdditional textE-mail"SPAM" filtering software notice Add to Clipboard Add to CollectionsOrder articles Add to My Bibliography Clin Cancer Res. 2009 Apr 1;15(7):2559-66. Epub 2009 Mar 24. Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. Fradet V, Cheng I, Casey G, Witte JS. SourceDepartments of Urology, Institute for Human Genetics, University of California at San Francisco, San Francisco, California 94143-0794, USA. Abstract PURPOSE: Dietary intake of long-chain omega-3 (LC n-3) polyunsaturated fatty acids may reduce inflammation and in turn decrease risk of prostate cancer development and progression. This potential effect may be modified by genetic variation in cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism and inflammation. EXPERIMENTAL DESIGN: We used a case-control study of 466 men diagnosed with aggressive prostate cancer and 478 age- and ethnicity-matched controls. Diet was assessed with a semiquantitative food frequency questionnaire, and nine COX-2 tag single nucleotide polymorphisms (SNP) were genotyped. We used logistic regression models to estimate odds ratios (OR) for association and interaction. RESULTS: Increasing intake of LC n-3 was strongly associated with a decreased risk of aggressive prostate cancer (P(trend) <or= 0.0001). The OR (95% confidence interval) for prostate cancer comparing the highest with the lowest quartile of n-3 intake was of 0.37 (0.25-0.54). The LC n-3 association was modified by SNP rs4648310 (+8897 A/G), flanking the 3' region of COX-2 (P(interaction) = 0.02). In particular, the inverse association was even stronger among men with this variant SNP. This reflected the observation that men with low LC n-3 intake and the variant rs4648310 SNP had an increased risk of disease (OR, 5.49; 95% confidence interval, 1.80-16.7), which was reversed by increasing intake of LC n-3. CONCLUSIONS: Dietary LC n-3 polyunsaturated fatty acids appear protective for aggressive prostate cancer, and this effect is modified by the COX-2 SNP rs4648310. Our findings support the hypothesis that LC n-3 may impact prostate inflammation and carcinogenesis through the COX-2 enzymatic pathway.
2 מחקרים עם תוצאות הפוכות ב 180 מעלות. המחקר הראשון שהראה כי אומגה 3 מגבירה גידול אגרסיבי היה פי 4 גדול בהיקפו מהמחקר שהראה תוצאה הפוכה.
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