גלוטמין מונע נוירופתיה של אוקסליפלאטין

1: Oncologist. 2007 Mar;12(3):312-9. Related Articles, Links Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients. Wang WS, Lin JK, Lin TC, Chen WS, Jiang JK, Wang HS, Chiou TJ, Liu JH, Yen CC, Chen PM. National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China. Oxaliplatin is effective in the treatment of metastatic colorectal cancer (MCRC) patients; however, severe neurotoxicity develops frequently. To assess the efficacy of oral glutamine for preventing neuropathy induced by oxaliplatin, a pilot study was performed. A total of 86 patients with MCRC treated at Taipei Veterans General Hospital were enrolled. Oxaliplatin (85 mg/m(2), days 1 AND 15) plus weekly bolus 5-fluorouracil (5-FU; 500 mg/m(2)) AND folinic acid (FA; 20 mg/m(2)) on days 1, 8, AND 15 were given every 28 days as first-line treatment. Patients were randomized to receive (glutamine group; n = 42) OR not receive (control group; n = 44) glutamine (15 g twice a day for seven consecutive days every 2 weeks starting on the day of oxaliplatin infusion). Efficacy of chemotherapy, neurological toxicity, AND electrophysiological alterations were assessed. A lower percentage of grade 1-2 peripheral neuropathy was observed in the glutamine group (16.7% versus 38.6%) after two cycles of treatment, AND a significantly lower incidence of grade 3-4 neuropathy was noted in the glutamine group after four cycles (4.8% versus 18.2%) AND six cycles (11.9% versus 31.8%). By adding glutamine, interference with activities of daily living was lower (16.7% versus 40.9%), AND need for oxaliplatin dose reduction was lower (7.1% versus 27.3%). There were no significant between-group differences in response to chemotherapy (52.4% versus 47.8%), electrophysiological abnormalities, grade 3-4 non-neurological toxicities (26.2% versus 22.8%), OR survival. These data indi-cate that oral glutamine significantly reduces the incidence AND severity of peripheral neuropathy of MCRC patients receiving oxaliplatin without affecting response to chemotherapy AND survival. Publication Types: Research Support, Non-U.S. Gov't PMID: 17405895 [PubMed - indexed for MEDLINE]

יש אבקת גלוטמין להשגה גם בארץ בבית מרקחת "נצח ישראל" (ת"א) כפית גדושה היא שוות ערך ל-5 גרם. 2 כפיות 3X /יום = 30 גר' קל לביצוע! בברכה, גובי