פאוכרומוציטומה.
דיון מתוך פורום אנדוקרינולוגיה והפרעות בגדילה בקרב ילדים
ההודעה נקטעה,סליחה. לפני כמה ימים פניתי אליך בנושא. יש סיכוי גדול שזה מה שיש לי. אודה אם תפנה אותי לחומר תאורטי רלוונטי-אפשר בעברית או באנגלית. תודה.
Pheochromocytoma is a tumor of the adrenal gland that causes excess release of epinephrine and norepinephrine, hormones that regulate heart rate and blood pressure. Pheochromocytoma may occur as a single tumor or as multiple growths. It usually develops in the medulla (center or core) of one or both adrenal glands. Sometimes this kind of tumor occurs outside the adrenal gland, usually somewhere else in the abdomen. Less than 10% of pheochromocytomas are malignant (cancerous), with the potential to spread to other parts of the body. The tumors may occur at any age, but they are most common in young-adult to mid-adult life. A common clinical feature is a paroxysm (an attack of symptoms listed below) that may be frequent but sporadic (occurring at unpredictable intervals). The paroxysms may increase in frequency, duration and severity as the tumor grows. Symptoms : headache , Palpitations , Rapid heart rate , Sweating , Flushing , Chest pain , Abdominal pain , Nervousness , Irritability, Increased appetite , Loss of weight, Additional symptoms that may be associated with this disease: Sleeping difficulty, Hand tremor , High blood pressure Signs and tests Vital signs (temperature, pulse, rate of breathing, blood pressure) reveal high blood pressure (hypertension) that may be sustained or episodic, rapid heart rate, and elevated temperature. Diagnosyic procedures: A that shows pheochromocytoma, A MIBG scintiscan that shows tumor, , An MRI of abdomen that shows adrenal mass, An abdominal CT scan that shows mass.Elevated urine metanephrine, Elevated urine catecholamines , Abnormal results of a glucose test , Abnormal levels of catecholamines - blood Treatment The definitive treatment is removal of the tumor by surgery. Continuous monitoring of all vital signs is necessary in the postoperative period in an intensive care unit. Stabilization of the person's vital signs with medication prior to surgery is important and may require hospitalization. In the case of an inoperable tumor, management with medication is necessary. Radiation therapy or chemotherapy have not been effective in curing this kind of tumor. Prognosis For patients who have noncancerous tumors that are removed with surgery, the 5-year survival rate is 95%, with recurrence in less than 10% of patients. Hormone secretion of norepinephrine and epinephrine returns to normal after surgery. For patients who have malignant tumors, the 5-year survival rate after surgery is less than 50%. Complications High blood pressure may not be cured in one-fourth of the people after surgery, yet control is usually achieved in these people with standard treatments for hypertension. Recurrence of tumor may occur in 10% of the cases
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תודה על המאמר. לצערי הוא ניקטע בחלקו. אודה לך אם תציין את מקור המאמר tאו באם ניתן יהיה להעבירו למייל שצויין למעלה על מנת שאוכל לקרוא עד סופו. תודה