הורמון להפחתת טוטסטרון

1 החומר הפעיל בשני הסוגים זהה- ציפרוטרון אצטט. אינני ממליץ על מינון דרך האינטרנט- עלייך לשאול את הרופאה על כך. אם לוקחים את הכדורים רק 15 ימים בחודש הסיכוי לתופעות לוואי קטן מאד. Medicine Info: Active Ingredients Cyroterone acet. (hormone inhibit) Mechanism: Hormone inhibitor. Antiandrogenic hormone preparation with antiandrogeic effect, progestational effect and antigonadotrophic effect. Blocks the effect of endrogenously produced and exogenously administered androgens at target organs by means of competitive inhibition. The inherent progestational activity exerts a negative feedback on the hypothalamic receptors leading to a reduction in gonadotropin release and therefore a diminished production of androgens. Indications: IN MEN: Reduction of drive in sexual deviations. Anti-androgen treatment in inoperable carcinoma of the prostate. IN WOMEN: Severe signs of androgenisation eg. very severe hirsutism, androgen- dependent severe loss of scalp hair eventually resulting in baldness (severe androgenic aloplecia), often attended by severe forms of acne and/or seborrhoea. IN CHILDREN: Idiopathic precocious puberty. Contra-Indications: Pregnancy and lactation. Liver disease. A history of jaundice or persistent itching during a previous pregnancy A history of herpes of pregnancy. Dubin-Johnson syndrome. Rotor syndrome. Previous or existing liver tumors ( in carcinoma of the prostate only if these are not due to metastases). Wasting disease (with the exception of carcinoma of the prostate). Depression. Previous or existing thromboembolic processes. Diabetes with vascular changes. Sickle cell anaemia. Diabetes with vascular changes. CONSIDER THE RISK AGAINST THE BENEFIT IN EACH CASE Dosage: Management of overdose: Symptoms: See "side-effects" Rx: Symptomatic and supportive. Side-Effects: Gradual reduction in the ability of man to procreate.(reversible on discontinuation of the drug or rarely with dose reduction). Gynaecomastia in men. In women ovulation is inhibited under combined cyclical treatment so that a state of infertility exists. Should a woman fall pregnant signs of feminisation in male neonates may occur. Tension in the breasts. High doses may reduce the function of the adrenal cortex, especially the adrenocortical response to stress. Tiredness, diminished vitality, occasionally temporary inner restlesness, depressive moods, changes in weight. Dyspnoea has been reported. Disturbances of liver function, acute and fulminant hepatitis has been reported on high doses. Liver tumors with intraabdominal haemorrhage may occur. Precautions: Cyproterone may lead to tiredness, diminished vitality, and impair the ability to concentrate...caution if driving/operating machinery until the individual response is known. Caution in patients with cardiovascular disease, ischaemic heart disease, cerebrovascular disease and hypertension. The sexual drive-reducing effect of cyproterone can be diminished under the disinhibitory effect of alcohol. Should not be given before the conclusion of puberty (with the exception of idiopathic precocious puberty) since it may affect longitudinal growth and the still unstabilised axes of endocrine function cannot be ruled out. Appropriate replacement therapy must be considered in children with idiopathic precocious puberty under stress (eg.surgery) because of the limitation of adrenocortical function under high doses of cyproterone. During treatment liver function, adrenocortical function and red blood cell count should be checked regularly. In diabetics carbohydrate metabolism should be monitored carefully. Women shoould have a thorough medical and gynaecological examination (including breasts) and pregnancy must be excluded. Since liver tumors with intraabdominal haemorrhage may occur ... patients should warn the doctor of unusual upper abdominal complaints which do not disappear spontaneously with-in a short time. If during combined cyclical treatment , slight "unscheduled" bleeding occurs, tablet taking should not be interrupted. However if bleeding is heavy, the patient shoould consult the doctor. Haemoglobin and red blood-cell count may decrease on therapy with cyproterone. Pregnancy: Before starting therapy women should have a thorough general medical and gynaecological examination (including breasts). Pregnancy must be excluded. Feminisation of the male foetus may occur. Porphyria: Contentious Sport: Banned