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בהחלט משפיע: מצ"ב אתר הכותב על כך ומתחתיו מה שמופיע באתר זה. http://www.prozactruth.com/paxil.htm Breaking News - Paxil - Seroxat "GSK" face charges by the FDA and the U.K . Healthcare Products Regulatory Agency Click Here Paxil CR - Seroxat (Paroxetine) Side Effects Body as a Whole: Infrequent were anaphylactoid reaction (allergic reaction), chills, flu syndrome, malaise (a vague feeling of bodily discomfort); also observed were adrenergic syndrome (one organ or body part mimicking the pain or distress of another body part), face edema (excessive fluid buildup in the face), neck rigidity, sepsis (a range of conditions which can run up to and include multiple organ failure and death). Cardiovascular System (heart and blood vessel system): Frequent were hypertension (high blood pressure), hypotension (low blood pressure); infrequent were angina pectoris (heat attack), bradycardia (abnormal slowing of the heartbeat), bundle branch block (a blocking of nerve impulses through the heart, causing it to malfunction), palpitation (speeding up of heartbeat), postural hypotension (decrease in blood pressure when sitting or standing), syncope (sudden loss of strength and/or fainting); also observed were arrhythmia nodal (irregular heartbeat), atrial fibrillation (loss of coordiated rhythm between sections of the heart), cerebrovascular accident (stroke), congestive heart failure (weakened heart), hematoma (blood clot), low cardiac output, myocardial infarct (failure of the heart muscle due to a blockage of circulation to it), myocardial ischemia (chest pain resulting from a spasm or narrowing of coronary arteries), pallor, phlebitis (inflammation of the wall of a blood vein), pulmonary embolus (blockage of an artery in the lungs), supraventricular extrasystoles (irregular contractions of the heart caused from a particular part of the heart), thrombophlebitis (inflammation of the wall of a blood vein preceding a blood clot), thrombosis (blood clot in a blood vessel or vein), vascular headache (headache associated with abnormally enlarging and shrinking of blood vessels in the head), ventricular extrasystoles (irregular contractions of the heart caused by a particular part of the heart). Back to top of page Digestive System: Infrequent were bruxism (clenching and grinding of teeth), dysphagia (difficulty in swallowing), eructation (belching), gastroenteritis (irritation and inflammation of the digestive tract), gastroesophageal reflux (heartburn), gingivitis (inflammation of the gums), glossitis (inflammation of the tongue), gum hyperplasia (an abnormal increase of cells in the gums), hemorrhoids, hepatosplenomegaly (enlargement of both the spleen and liver), increased salivation, intestinal obstruction, melena (blood in the stool), pancreatitis (inflammation of the pancreas), peptic ulcer (sore on the lining of the stomach), rectal hemorrhage (bleeding from the rectum), stomach ulcer, toothache, ulcerative stomatitis (inflammation of the mouth, with open sores); also observed were aphthous stomatitis (canker sores), bloody diarrhea, bulimia, cardiospasm (spasm of the passage to the stomach, blocking the stomach), cholelithiasis (gall stones), colitis (inflammation of the colon), duodenitis (inflammation of part of the small intestine), enteritis (inflammation of the intestines), esophagitis (inflammation of the esophagus, part of the throat), fecal impactions (clogged bowels), fecal incontinence (inability to control bowel movements), gastritis (inflammation of the stomach), gum hemorrhage (bleeding gums), hematemesis (vomiting of blood), hepatitis (inflammation of the liver), ileitis (inflammation of part of the small or large intestine), ileus (ceasing of bowel movements), jaundice, mouth ulceration (open sores in mouth), salivary gland enlargement, sialadenitis (salivary gland infection), stomatitis (mouth inflammation), throat tightness, tongue discoloration, tongue edema (over-buildup of fluid in the tongue). Back to top of page Endocrine System (system of glands in the body that regulate, among other things, body weight): Infrequent were hyperthyroidism (overactive thyroid gland), ovarian cyst (sac of fluid grown on an ovary or on ovaries), testes pain; also observed were diabetes mellitus (a condition of high blood sugar), goiter (swelling of the thyroid gland, often seen as a large swelling in the front of the neck), hypothyroidism (underactivity of the thyroid gland), thyroiditis (inflammation of the thyroid gland). Hemic and Lymphatic System (blood and related systems): Infrequent were anemia (lack of red blood cells), eosinophilia (an abnormally high amount of a type of white blood cell), leukocytosis (abnormal increase in white blood cells), leukopenia (reduction of white blood cells), lymphadenopathy (a cancerous disorder of the lymph gland), thrombocytopenia (a decrease, within the blood, of a special type of cell called a platelet); also observed were anisocytosis (abnormal variation in the size of red blood cells), basophilia (an increase in the number of a certain type of white blood cells), bleeding time increased, hypochromic anemia (a reduction both in size and volume of red blood cells), lymphedema (an overabundance of a fluid called lymph, often resulting in swelling), lymphocytosis (excess of a particular type of white blood cells), lymphopenia (a condition in which there are a low number of a particular type of white blood cells in the blood -- cells vital for the fighting of infection), microcytic anemia (a disease characterized by blood elements called erythrocytes being smaller than normal), monocytosis (an abnormal increase in a particular type of cell in the blood), normocytic anemia (low number of red blood cells), thrombocythemia (an increase in platelets -- a special type of cell -- in the blood). Back to top of page Metabolic and Nutritional Disorders (dealing with digestion and related areas): Infrequent were bilirubinemia (an elevated level in the blood of a substance called biliruben, causing jaundice, yellowing of the whites of the eyes, and other problems), dehydration, generalized edema (buildup of fluid in the tissues), hyperglycemia (an overabundance of sugar in the blood), hyperkalemia (abnormally high amount of potassium in the blood), hypokalemia (abnormally low amount of potassium in the blood), peripheral edema (buildup of fluid nearer the outside of the body) , SGOT increased (the results of a test on an enzyme called SGOT, which is used to measure the function of the liver, kidney, heart, pancreas, muscles, and red blood cells), SGPT increased (the results of a test on an enzyme known as SGPT, the presence of which in the blood indicates liver damage), thirst; also observed were alkaline phosphatase increased (an enzyme, the presence of which in the blood indicates liver damage), BUN (blood urea nitrogen) increased (indicates kidney malfunction), creatinine phosphokinase increased (increase of an enzyme which may indicate muscular distrophy, a disease which causes permanent muscle breakdown), gamma globulins increased (increase in a part of blood which carries antibodies), gout (inflammation of the joints, especially the big toe), hypercalcemia (excessive calcium in the blood), hypercholesteremia (an excess of cholesterol in the blood), hyperphosphatemia (a high amount of phosphate in the blood, leading to uncoordination of muscles and which can lead to severe organ failure), hypocalcemia (lowered calcium in the blood, which can lead to serious illness and even death), hypoglycemia (a lower amount of blood sugar, causing weakness, dizziness and confusion), hyponatremia (lowering of sodium in the body, which can cause nausea, muscle cramps, disorientation, slurred speech, confusion, and inappropriate behavior), ketosis (presence in the body of elements called ketones, which is under debate as to being good or bad), lactic dehydrogenase increased (a particular enzyme relating to milk increased), non-protein nitrogen (NPN) increased. Back to top of page Musculoskeletal (muscular and skeletal) System: Infrequent were arthritis, bursitis (inflammation of a bursa, a pouch of lubricating fluid between a muscle and a bone), myasthenia (debilitation of a muscle or muscles), myopathy (diseased muscles), myositis (muscle inflammation), tendonitis (tendon inflammation); also observed were generalized spasm, osteoporosis (bone deterioration), tenosynovitis (inflammation of the sheath which holds a tendon), tetany (spasms of the wrist and ankle joints). Nervous System: Infrequent were amnesia, ataxia (inability to coordinate muscle movement), convulsion, diplopia (double vision), dystonia (muscle problems), emotional lability (instability), hallucinations, hypesthesia (partial loss of sensation), hypokinesia (decreased mobility), incoordination (inability to move the body correctly), neuralgia (sharp pain along a nerve), neuropathy (functional disturbances in the outer nervous system), nystagmus (unnatural and rapid movement of the eye), paralysis, paranoid reaction, vertigo (dizziness and loss of balance), withdrawal syndrome; also observed were abnormal gait (inability to walk properly), akathisis (nervous restlessness), akinesia (inability to move properly), aphasia (speech impediment), choreoathetosis (continuous and uncontrolled involuntary movement), circumoral paresthesia (strange sensations in the mouth), delirium (a state of mind which manifests itself in irrational talk and hallucinations), delusions, dysarthria (speech impediment), dyskinesia (involuntary muscle movement), euphoria, extrapyramidal syndrome (abnormal movements through certain parts of the nervous system), fasciculations (muscle contractions), grand mal convulsion (epileptic and heavy convulsion), hostility, hyperalgesia (excessive sensitivity to pain), irritability, libido increased (sex drive increased), manic reaction (great excitement, rage), manic-depressive reaction (great excitement and rage, followed by depression, which this drug is supposed to prevent; in fact, this drug is prescribed for manic-depression, otherwise known is bipolar syndrome), meningitis (inflammation of the membranes that protect the brain and spinal cord, resulting in serious and sometimes fatal illness), myelitis (inflammation of the spinal cord or of bone marrow), peripheral neuritis (inflammation of nerve endings), psychosis, psychotic depression (something this drug is supposed to treat and prevent), reflexes decreased, reflexes increased, stupor, torticollis (twisted state of the neck), trismus (lockjaw). Back to top of page Respiratory System (relating to lungs and breathing systems): Infrequent were asthma, dyspnea (difficulty breathing), epistaxis (nosebleed) , laryngitis (inflammation of a portion of the throat which makes it near-impossible to talk), pneumonia, stridor (high-pitched sound when breathing is obstructed); also observed were dysphonia (impairment of voice), emphysema (buildup of fluid in lungs), hemoptysis (coughing up blood), hiccups, hyperventilation, lung fibrosis (growth of excess fibrous matter in the lung), pulmonary edema (excess fluid in the lungs), respiratory flu, sputum (mixture of mucus and saliva, let out through the mouth) increased. Skin and Appendages: Infrequent were acne, alopecia (loss of hair), dry skin, eczema (flaking, dry skin), exfoliative dermatitis (inflamed skin coming off in scales), furunculosis (painful sores), pruritus (skin inflammation), seborrhea (abnormally oily skin), urticaria (hives); also observed were angioedema (excess of fluid in the tissues of blood vessels), ecchymosis (bleeding under the skin), erythema multiforme (severe skin irritation), erythema nodosum (severe skin irritation), hirsutism (abnormal hairiness), maculopapular rash (rash consisting of blotches and bumps), skin discoloration, skin hypertrophy (skin swelling), skin ulcer (open sore on skin), sweating decreased, vesiculobullous (blisters on the skin) rash. Back to top of page Special Senses: Infrequent were abnormality of accommodation (trouble seeing distances), conjunctivitis (inflammation of the inner eyelids), earache, keratoconjunctivitis (inflammation of both the inner eyelid and the inner covering of the eye), mydriasis (extreme enlargement of the pupil of the eye), photophobia (inability to tolerate light), retinal hemorrhage (bleeding from the eye), tinnitus (ringing or clicking in the ears), visual field defect (not having a normal field of vision); also observed were amblyopia (dimness of vision), anisocoria (having pupils of different size), blepharitis (inflammation of the eyelids), blurred vision, cataract (cloudy formation on the eye, often resulting in partial blindness), conjunctival edema (excessive fluid built up in eyelids), corneal ulcer (open sore on the eye covering), deafness, exophthalmos (abnormal protrusion of the eyeball), glaucoma (disease of the eyes resulting in gradual loss of sight), hyperacusis (abnormal hearing sensitivity), night blindness, parosmia (altering of the sense of smell), ptosis (drooping of the eyelid), taste loss. Urogenital System (urine and reproductive systems): Infrequent were albuminuria (presence in urine of albumin, a part of the blood), amenorrhea (stopping of menstrual cycle) , breast enlargement, breast pain, cystitis (inflammation of the bladder), dysuria (pain while urinating), hematuria (blood in urine), kidney calculus (kidney stones), menorrhagia (menstrual distress), nocturia (excessive urination at night), prostatitis (inflammation of the prostate), urinary incontinence (inability to control urination), urinary retention; also observed were breast atrophy (breast diseased), ejaculatory disturbance (ejaculation too soon, too late, not at all, etc.), endometrial disorder (disorder with the lining of the uterus), epididymitis (inflammation of the epididymus, a structure within the testes of males), female lactation (leaking of milk from breasts), fibrocystic breast (growths within the breast), leukorrhea (vaginal discharge), mastitis (inflammation of the mammary gland), metrorrhagia (irregular uterine bleeding), nephritis (inflammation of the kidney), oliguria (secretion of a diminished amount of urine in relation to the fluid intake), polyuria (passage of a large volume of urine in a given period of time), pyuria (presence of pus in urine), salpingitis (inflammation of the uterine tube in females), urethritis (inflammation of the urethra, the passage through which urine leaves the body), urinary casts (mineral objects discharged with urine), urinary urgency (having to urinate badly), urolith (stones in the urinary tract), uterine spasm, vaginal hemorrhage (bleeding from the vagina). Back to top of page Postmarketing Reports Voluntary reports of adverse events in patients taking immediate-release paroxetine hydrochloride that have been received since market introduction and not listed above that may have no causal relationship with the drug include acute pancreatitis (temporary inflammation of the pancreas), elevated liver function tests (the most severe cases were deaths due to liver necrosis [complete failure of the liver], and grossly elevated transaminases [a type of enzyme] associated with severe liver dysfunction), Guillain-Barré syndrome (an acute disease of the peripheral nervous system in which the nerves in the arms and legs become inflamed and stop working, causing sudden weakness leading to limb paralysis, and a loss of sensation, sometimes with pain), toxic epidermal necrolysis (a life-threatening skin disorder characterized by a blistering and peeling of the top layer of skin), priapism (persistent painful erection of the penis), syndrome of inappropriate ADH secretion (a condition which causes water not to be absorbed by the body), symptoms suggestive of prolactinemia (a glandular disorder which can cause a wide variety of female organ problems) and galactorrhea (excessive or spontaneous flow of mother's milk), neuroleptic malignant syndrome (a very serious drug reaction which includes fever, rigidity and psychosis)-like events; extrapyramidal (dealing with a particular portion of the nervous system) symptoms which have included akathisia (restlessness; inability to sit still), bradykinesia (abnormally slow movements), cogwheel rigidity (rigidity of a muscle that gives way in a series of little jerks upon being stretched by another), dystonia (muscle problems), hypertonia (abnormal tension of arteries or muscles), oculogyric crisis (A spasmodic movement of the eyeballs into a fixed position, usually upward, that persists for several minutes or hours) which has been associated with concomitant (simultaneous) use of pimozide (an antipsychotic drug), tremor and trismus (lockjaw); serotonin syndrome (a state which is a very dangerous and a potentially fatal side effect of serotonin-related drugs -- of which Paxil is one -- which can have multiple psychiatric and non-psychiatric symptoms), associated in some cases with concomitant (simultaneous) use of other serotonergic drugs and with drugs which may have impaired paroxetine (Paxil) metabolism (note that Paxil itself can inhibit this metabolism) (symptoms have included agitation, confusion, diaphoresis [medically-induced heavy perspiration], hallucinations, hyperreflexia [usually only occurs with spinal injury and contains symptoms such as pounding headache and restlessness], myoclonus [sharp muscle contractions], shivering, tachycardia [extremely rapid heartbeat] and tremor); status epilepticus (a continuous seizure), acute renal failure (temporary failure of the kidneys), pulmonary hypertension (elevated blood pressure in a main artery of a lung), allergic alveolitis (inflammation of the areas behind teeth as an allergic reaction), anaphylaxis (life-threatening rapid allergic reaction), eclampsia (a condition in women in the late stages of pregnancy which includes high blood-pressure and fluid buildup. It may require emergency delivery of the baby), laryngismus (illness in which spasms of the larynx, part of the throat, occur) optic neuritis (inflammation of the optic nerve), porphyria (a disease which consists of a group of related diseases, during which the afflicted experiences abdominal pain, vomiting, constipation and cramps, and can be fatal), ventricular fibrillation (loss of coordiated rhythm between sections of the heart), ventricular tachycardia (extremely rapid heartbeat in part of the heart) (including torsade de pointes [a variant of ventricular tachycardia]), thrombocytopenia (a decrease, within the blood, of a special type of cell called a platelet), hemolytic anemia (a sickness and dying of red blood cells combined with an inability of the bone marrow to replace them), and events related to impaired hematopoiesis (formation of blood cells) (including aplastic anemia [failure of the bone marrow to produce red blood cells], pancytopenia [a deficiency of all types of blood cells], bone marrow aplasia [lack of bone marrow development], and agranulocytosis [lack of a particular type of white blood cells, lowering immunity to disease]) and vasculitic (dealing with inflammation of blood vessels) syndromes (such as Henoch-Schönlein purpura [inflammation of blood cells]). There has been a case report of an elevated phenytoin (an anti-convulsant drug) level after 4 weeks of immediate-release paroxetine (Paxil) and phenytoin (an anti-convulsive drug) co-administration. There has been a case report of severe hypotension (lowered blood pressure) when immediate-release paroxetine was added to chronic metoprolol (a drug used to treat high blood pressure) treatment. Back to top of page *The Paxil - Seroxat side effects (underlined) listed below, are linked to case studies that have determined glutathione depletion and certain side effects go hand in hand. Almost all of the Paxil - Seroxat side effects listed below are a result of low glutathione in the cells of the body. Other case studies will be added ASAP. The chemical properties, in the structure of Paxil - Seroxat, lower glutathione levels in your cellular structure. A psychiatrist may have been the one to prescribe Paxil - Seroxat but a Chemist can easily determine why chemically induced Paxil - Seroxat side effects take place. Back to top of page Paxil - Seroxat (Paroxetine) Side Effects Frequent - Paxil - Seroxat (Paroxetine) Side Effects Body as a Whole: Malaise (a vague feeling of bodily discomfort), pain. Cardiovascular: Hypertension, syncope (a sudden loss of strength, a temporary suspension of consciousness due to cerebral anemia), tachycardia (excessive rapidity in the action of the heart). Dermatological: Pruritus (Intense itching) Gastrointestinal: Nausea and vomiting. Metabolic and Nutritional: Weight gain, weight loss. Nervous System: Central Nervous System stimulation, concentration impaired, depression, emotional lability (emotional instability), vertigo (a hallucination of movement; a sensation as if the external world were revolving around the patient or as if he himself were revolving in space). Respiratory: Cough increased, rhinitis (inflammation of the mucus membrane of the nose). Back to top of page Infrequent - Paxil - Seroxat (Paroxetine) Side Effects Infrequent Paxil - Seroxat side effects occurred in at least 1 in 1000 people. Body as a Whole: Allergic reaction, chills, face edema (abnormal amount of fluid in the facial tissue), infection, moniliasis (infection caused by Candida (yeast like fungi), neck pain, overdose. Cardiovascular: Bradycardia (abnormal slowness of the heartbeat), conduction abnormalities (abnormal transfer of sound waves, heat, nerve influences, or electricity), ECG abnormal, hypotension (lowered blood pressure), migraine, ventricular extrasystoles (a premature contraction of the heart). Dermatological: Acne, alopecia (absence of hair from the body where it is normally present), dry skin, ecchymosis (blood under the skin, usually looks or appears like a bruise), eczema (an inflammatory skin disease characterized by lesions varying greatly in character, at times watery discharge and the development of scales and crust), furunculosis (a number of painful nodules formed in the skin, caused by bacteria, which enter through the hair follicles or glands, its formation is favored by digestive derangement and local irritation), herpes simplex, urticaria (reaction of the skin to certain drugs, marked by the appearance of smooth, slightly elevated patches, which are redder or paler than the surrounding skin and often includes severe itching). Gastrointestinal: Bruxism (grinding of the teeth especially during sleep), buccal cavity disorders (cavity running from the cheeks to the lips), dysphagia (inflammation of the esophagus), eructation (the act of belching or casting up wind from the stomach), gastroentertitis (inflammation of the stomach or intestines), gastrointestinal flu, glossitis (inflammation of the tongue), increased salivation, liver function test abnormal, mouth ulceration, vomiting and diarrhea, rectal hemorrhage. Hematologic and Lymphatic: Anemia, leukopenia (reduction in the number of leukocytes in the blood), lymphadenopathy (disease of the lymphnodes), purpura (condition charactized by the presence of blood just under the skin, can appear any where over the body), WBC abnormality (white blood cell abnormality). Musculoskeletal: Arthralgia (pain in the joint), arthritis, traumatic fracture. Nervous System: Akinesia (the temporary paralysis of a muscle, can include intense pain), alcohol abuse, amnesia, ataxia (failure of muscular coordination or irregularity of muscle action), convulsion, depersonalization, hallucinations, hyperkinesia (abnormally increased mobility, abnormally increased motor function or activity), hypertonia (a condition of excessive tone, tension or activity, can include increased blood pressure), incoordination, lack of emotion, manic reaction, paranoid reaction, thinking abnormal. Respiratory: Asthma, bronchitis, dyspnea (difficult or labored breathing), epistaxis (hemorrhage from the nose), hyperventilation, pneumonia, respiratory flu, sinusitis. Special Senses: Abnormality of accommodation, conjunctivitis, ear pain, eye pain, mydriasis (extreme or morbid dilation of the pupil), otitis media (inflammation of the ear which may be marked by pain, fever, abnormalities of hearing, deafness, tinnitus, and vertigo), tinnitus (a noise in the ear, as ringing, buzzing, roaring clicking etc). Urogenital: Abortion*, amenorrhea* (absence or abnormal stoppage of menses), breast pain*, cystitis (inflammation of the urinary bladder), dysmenorrhea* (painful menstruation), dysuria (painful or difficult urination), menorrhagia* (excessive uterine bleeding occurring at regular intervals), nocturia (excessive urination at night), polyuria (the passage of a large volume of urine in a given period), urinary incontinence, urinary retention, urinary tract infection, urinary urgency, vaginitis* (inflammation of the vagina). * Gender specific Back to top of page Are you having a difficult time quitting Paxil - Seroxat? Click Here Do you to keep taking Paxil - Seroxat but you want to get rid of the side effects or help protect your body from the Paxil - Seroxat toxins? Click Here June 6, 2001. Wyoming Jury Awards $6 Million in Paxil - Seroxat Related Murder/Suicide If you are currently taking or thinking of starting psychiatric medication, this is a must read. "Certain kinds of antidepressants can double the risk of developing breast cancer, according to a landmark Canadian study." This is a must read for Paxil - Seroxat users. *February 2, 2002. News - Withdrawal from Paroxetine can be severe, warns FDA "and in the same week the International Federation of Pharmaceutical Manufacturers Associations declared the company guilty of misleading the public about Paroxetine on US television a year ago." This is not new news to most of the people that have tried to quit taking Paxil - Seroxat. Having side effects from Paxil - Seroxat? Want an Attorney? Click Here * December 12, 2001. FDA states "Paxil - Seroxat employed a taper phase regimen, rather than an abrupt discontinuation of treatment..." Click here to read excerpt. *Please note: Paxil - Seroxat is extensively metabolized in the liver. Clinical trials show 64% of the Paxil - Seroxat ingested will be eliminated through the kidneys and 36% of Paxil - Seroxat will be eliminated in the feces. * Paxil - Seroxat Litigation April 26, 2002 Canadian Class Action: Because of the severe adverse effects, including physical and psychological withdrawal symptoms, that many people have been experiencing from using Paxil - Seroxat, Poyner Baxter Law Firm has filed a class action lawsuit against GlaxoSmithKline (the manufacturer). Specifically, the suit we have filed includes claims for persons who have reduced their dosage of Paxil - Seroxat or discontinued use of the drug and experienced either physical or psychological withdrawal symptoms. Read Class Action Click Here Opens new Browser window 16% of all people given Paxil - Seroxat in a worldwide clinical trial discontinued treatment of Paxil - Seroxat due to an adverse experience. What are the real Paxil - Seroxat side effects? Click here This is only a short list of what really happens while using Paxil - Seroxat. Back to top of page More Paxil - Seroxat Side Effects Click here Paxil - Seroxat side effects, as well as other SSRI side effects, are not just for one day or one hour. They are generally with you the entire time you take the medication. If you are ready to quit taking Paxil - Seroxat or have already quit but still suffering from side effects, Click Here. Would you like to see real side effects as described by people that have used an