חשיבות נטילת טירוקסין בהדרגה

שווה קריאה,במיוחד לרופא שזה עיסוקו: Long standing hypothyroidism is associated with atherogenesis, which may or may not manifest itself in the hypometabolic state. In such cases levothyroxine should be administered with extreme caution employing low initial dosage increased slowly by small increments, as even a gradual restoration of normal metabolic rate may result in development or exacerbation of myocardial ischemia and angina. In some patients, cardiovascular status may be so compromised that the metabolic demands of the euthyroid state cannot be met, despite the employment of appropriate antianginal therapy. Clinical judgment may then dictate a less-than-complete restoration of thyroid status. זה מסביר מדוע כשאנו עוברים לתרופה אחרת באותו המינון של התרופה הקודמת - רע לנו ויש תופעות לוואי .... צריך לעבור בהדרגה בהדרגה !!! זה המסר הכי חשוב. ועכשיו זה, Adjustment of levothyroxine dosage should be based mainly on the patient's clinical response and confirmed by appropriate laboratory tests. Laboratory tests alone should not be relied upon to guide therapy. Patients should immediately report to the physician experiences during the course of therapy of any signs or symptoms of thyroid hormone toxicity, e.g., chest pain, increased pulse rate, palpitations, excessive sweating, heat intolerance, nervousness, or any other unusual event. והנה הכתובת למקור: http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20E)/ELTROXIN.html