ARIMIDIX

שלום בהחלט נכון שישנו שימוש בעולם במה שנקראים aromatase inhibitors לטיפול במקרים קשים של פריון הגבר עם שיפור בפרמטרים של הזרע במיוחד בקבוצה שהיחס טסטוסטרון /אסטרוגן הוא לרעת הטסטוסטרון והעכוב באינזים משפר את המהרך ההורמונלי התוך אשכי לטובת שיפור במדדי הזרע,כפי שיעיד מאמר חדש זה Result FiltersDisplay Settings:AbstractFormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListApply Send to:Choose DestinationFileClipboardCollectionsE-mailOrderMy BibliographyCitation manager FormatSummary (text)Abstract (text)MEDLINEXMLPMID ListCSVCreate File 1 selected item: 22579129FormatSummarySummary (text)AbstractAbstract (text)MEDLINEXMLPMID ListMeSH and Other DataE-mailSubjectAdditional textE-mail"SPAM" filtering software notice Add to Clipboard Add to CollectionsOrder articles Add to My BibliographyGenerate a file for use with external citation management software. Create File Fertil Steril. 2012 Jul;98(1):48-51. Epub 2012 May 11. Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios. Gregoriou O, Bakas P, Grigoriadis C, Creatsa M, Hassiakos D, Creatsas G. Source2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens, Greece. [email protected] Abstract OBJECTIVE: To compare the effects of 2.5 mg letrozole with those of 1 mg anastrazole daily on the hormonal and semen profiles of a subset of infertile men with low T/E(2) ratios. DESIGN: Prospective, nonrandomized study. SETTING: Reproductive medicine clinic. PATIENT(S): The study group consisted of 29 infertile men with a low serum T/E(2) ratio (<10). INTERVENTION(S): Patients were divided into two groups. Group A included 15 patients treated with 2.5 mg letrozole orally once daily for 6 months, and Group B consisted of 14 patients treated with 1 mg anastrazole orally every day for 6 months. MAIN OUTCOME MEASURE(S): Hormonal evaluation included measurement of serum FSH, LH, PRL, T, and E(2). In all sperm analyses pretreatment and posttreatment total motile sperm counts (ejaculate volume × concentration × motile fraction) were evaluated. RESULT(S): The use of aromatase inhibitors (either letrozole or anastrazole) in cases of infertile men with low T/E(2) ratios improved both hormonal and semen parameters. CONCLUSION(S): This study suggests that some men with severe oligospermia, low T levels, and normal gonadotropin concentration may have a treatable endocrinopathy. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. PMID:22579129[PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, SubstancesPublication TypesClinical TrialMeSH TermsAdultAromatase Inhibitors/adverse effectsAromatase Inhibitors/pharmacologyAromatase Inhibitors/therapeutic use*Estradiol/analysisEstradiol/blood*Hormones/blood*Hormones/metabolismHumansInfertility, Male/bloodInfertility, Male/drug therapy*Infertility, Male/pathologyMaleNitriles/adverse effectsNitriles/pharmacologyNitriles/therapeutic useOrgan Size/drug effectsSemen Analysis*Testis/drug effectsTestis/pathologyTestosterone/analysisTestosterone/blood*Triazoles/adverse effectsTriazoles/pharmacologyTriazoles/therapeutic useSubstancesAromatase InhibitorsHormonesNitrilesTriazolesletrozoleanastrozoleEstradiolTestosterone LinkOut - more resources