סרקוואל או קלונקס שוב

פריון הגבר - בנק הזרע סרקוואל, או קלונקס תשובת מומחה אני 1תגובות 18/06/13 | 19:06 RE: סרקוואל, או קלונקס פרופ' יעקב אשכנזי 19/06/13 | 11:06 יתכן ולסרנדה ישנה פעילות ספרמיצידית הפוגעת בזרע-להלן מאמר: Bioorg Med Chem Lett. 2006 May 1;16(9):2509-12. Epub 2006 Feb 7. The spermicidal and antitrichomonas activities of SSRI antidepressants. Kumar VS, Sharma VL, Tiwari P, Singh D, Maikhuri JP, Gupta G, Singh MM. Source Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow-226001, India. Abstract The study investigated spermicidal and antitrichomonas activities of selective serotonin reuptake inhibitor (SSRI) antidepressants with a view to generate new lead for development of dual-function spermicidal microbicides, which is an urgent global need. Fluoxetine, Sertraline, and Fluvoxamine exhibited both spermicidal and anti-STI (antitrichomonas) activities in vitro, whereas Paroxetine and Citalopram showed only the spermicidal activity. Fluoxetine exhibited better activity profile than the other antidepressant drugs with its spermicidal and antitrichomonas activities being comparable to that of the OTC contraceptive Nonoxynol-9. The non-detergent nature of Fluoxetine and a much lower spermicidal ED50 value (than N-9) may add considerably to its merit as a candidate for microbicidal contraceptive. Thus, the antidepressants exhibiting both spermicidal and antitrichomonas activities might provide useful lead for the development of novel, dual-function spermicidal contraceptives. Gaoxiong Yi Xue Ke Xue Za Zhi. 1990 Jun;6(6):295-301. כלונקס עלול לפגוע בתנועתיות הזרע להלן מאמר: The inhibitory effect of anticonvulsants on human sperm motility: measured with a trans-membrane migration method. Shen MR, Chen SS. Source Department of Physiology, Kaohsiung Medical College, Taiwan, Republic of China. Abstract The in-vitro effects of four anticonvulsant drugs (phenytoin, phenobarbitone, carbamazepine and valproate) on human sperm motility were studied with a trans-membrane migration method. Sperm motility was measured either immediately after semen had been mixed with the drug or after a 2-hour pre-incubation at 37 degrees C. When the drug effect was evaluated after the semen-drug mixture had been pre-incubated for 2 hours, the concentration of phenytoin, carbamazepine and valproate that inhibited sperm motility to 50% of control (EC50) was 1.59, 4.23, and 5.00 mM, respectively. If sperm motility was immediately measured without preincubation, the EC50 was increased to 8.47 and 100.00 mM for carbamazepine and valproate, respectively, whereas phenytoin could not inhibit sperm motility to less than 50% of the control at the tested concentrations. Both with and without pre-incubation, phenobarbitone, even up to 12.92 mM, could not inhibit sperm motility to less than 50% of the control. The result was compatible with previous findings that drugs with a membrane stabilizing effect may inhibit human sperm motility. This study provided further information regarding the application of human sperm motility as a cellular model for future pharmacological research. Drugs. 2004;64(20):2291-314. סרקוואל יכול לגרום לעליית הפרולקטין שיכולה לגרום לירידה ברמות ההורמונים FSH ו-LH ובעקבותיהם ירידה ברמת הטסטוסטרון ומכאן גם השפעה על הזרע ובנוסף לגרום לירידה בליבידו.להלן מאמר בנושא: Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management. Haddad PM, Wieck A. Source Bolton, Salford