iui עם זרע בעל מורפולוגיה נמוכה

כדי לכוון אותך בנושא חשוב זה עלי להפנות אותך לשני מאמרים חשובים שהופיעו לפני עשור-הראשון מנסה לתחום את הטווח התחתון של מדדי הזרע לטיפול שבעקבותיו ישנה ירידה משמעותית בשיעורי ההריון המושגים-כאמור מתחת למיליון תאי זרע בתנועה לאחר ההשבחה,ומופרפולוגיה תקינה מתחת ל-5% -להלן המאמר: Reprod Biomed Online. 2003 Oct-Nov;7(4):485-92. Semen quality and intrauterine insemination. Ombelet W, Deblaere K, Bosmans E, Cox A, Jacobs P, Janssen M, Nijs M. Author information • Genk Institute for Fertility Technology, Schiepse Bos 6, 3600 Genk, Belgium. [email protected] Abstract There is good evidence in literature that intrauterine insemination (IUI) is the best first line treatment and most cost-effective procedure for moderate male factor subfertility. It seems very difficult to identify individual semen parameters predicting the likelihood of pregnancy after IUI. This can be explained by a lack of standardization of semen analysis, but many other methodological variables may also influence IUI success rates such as the patient selection, type of ovarian stimulation and number of inseminations per cycle. A review of the literature confirmed that sperm morphology using strict criteria and the inseminating motile sperm count (IMC) after sperm preparation are the two most important sperm parameters to assess the real impact of semen quality on IUI outcome. A universal threshold level above which IUI can be performed with acceptable pregnancy rates has not been determined yet, although IUI success seems to be impaired with <5% normal spermatozoa and an IMC of <1 x 10(6). Until now, no method of sperm preparation has been shown to be superior with regard to pregnancy rate after IUI. Whether supplementation of culture media with substances such as antioxidants and platelet activating factor may improve the results remains the subject of further research. יחד עם זאת במאמר אחר שמקורו בארץ הושג שיעור הריון סביר גם במצבים שהמופרפולוגיה התקינה היתה פחות מ-4% -להלן המאמר: Andrologia. 2001 Jan;33(1):13-7. Intrauterine insemination in male factor subfertility: significance of sperm motility and morphology assessed by strict criteria. Hauser R, Yogev L, Botchan A, Lessing JB, Paz G, Yavetz H. Author information • The Institute for the Study of Fertility, and Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel. Abstract The study was conducted to evaluate the results of IUI treatment in a homogenous group with male factor infertility, and to assess the correlation of sperm variables, including sperm morphology by strict criteria, with pregnancy achievement after IUI. A total of 108 couples with no apparent female aetiology for infertility underwent 264 intrauterine insemination treatment cycles. A comparison was made between the sperm variables in two groups in which the achievement of pregnancy differed. The percentage of motile spermatozoa, degree of motility and normal morphology (by strict criteria) were significantly higher in the pregnant group compared with that of the nonpregnant group. A significant difference in pregnancy rates per couple after intrauterine insemination was demonstrated among three groups according to the percentage of sperm morphology, i.e. poor (< 4%), fair (4-14%) or good (> 14%) (11.1%; 36.1% and 50.0%, respectively). Intrauterine insemination is a valid mode of treatment in cases with male infertility, provided that normal morphology by strict criteria is higher than 4%.