בדיקת הלוספרם והפלות חוזרות

עבודות רבות וכולל עבודת מחקר מהשנה מצביעות על הקשר האפשרי בין שברים ב-DNA של הזרע ושיעור הפלות גבוה ,ולכן בהחלט יש מקום בביצוע בדיקת ההלוספרם כחלק מהבירור של הפלות חוזרות-להלן המאמר: Andrologia. 2014 Mar;46(2):126-30. doi: 10.1111/and.12056. Epub 2012 Dec 20. Sperm DNA fragmentation in couples with unexplained recurrent spontaneous abortions. Khadem N1, Poorhoseyni A, Jalali M, Akbary A, Heydari ST. Author information 1Women's Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Abstract The aim of the present study was to evaluate the degree of sperm DNA fragmentation in couples with idiopathic recurrent spontaneous abortion (RSA) and in those with no history of infertility or abortion. In this cohort study, 30 couples with RSA and 30 fertile couples as control group completed the demographic data questionnaires, and their semen samples were analysed according to World Health Organization (WHO) standards (September 2009-March 2010) for evaluation of sperm DNA fragmentation, using sperm chromatin dispersion (SCD) technique. The percentage of morphologically normal sperm was significantly lower in RSA patients compared with control group (51.50 ± 11.60 versus 58.00 ± 9.05, P = 0.019), but not in other parameters. Additionally, the level of abnormal DNA fragmentation in the RSA group was significantly higher than in the control group (43.3% versus 16.7%, P = 0.024). Our results indicated a negative correlation between the number of sperm with progressive motility and DNA fragmentation (r = -0.613; P < 0.001). The sperm from men with a history of RSA had a higher incidence of DNA fragmentation and poor motility than those of the control group, indicating a possible relationship between idiopathic RSA and DNA fragmentation